The Cardinals placed Mathis on injured reserve Saturday,
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The team also lost fellow starting guard Mike Iupati to an ankle injury Thursday night. Earl Watford took over at right guard for Mathis,
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The Cardinals also signed guard/tackle Ulrick John from Miami's practice squad,
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TEMPE, Ariz. (AP) — Arizona Cardinals guard Evan Mathis will miss the rest of the season because of an ankle injury.
The 34-year-old Mathis signed with the Cardinals as a free after starting for Super Bowl champion Denver last season